Regulation of selective autophagy: the p62SQSTM1 paradigm

p62 com  The purpose of this review is to outline recent advances in understanding of the multiple pathophysiological roles of SQSTM1p62 protein  View HumanMouseRat p62SQSTM1 Biotinylated Antibody validated in Human, Mouse and Rat Additional non-catalog clones available

We show that inhibition of S-acylation regulates the abundance of several key regulators of autophagy and leads to a partial block of autophagic flux  p62 is the protein encoded by the Sqstm1 gene and has important cellular functions In addition to the well-known role of p62 in facilitating selective

We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 ( Labeling of p62 serves as a useful marker for the induction of autophagy, clearance of protein aggregates, and the inhibition of autophagy Labeling of LC3B